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Graduate Seminar Featuring Victor Barocas

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September 3 @ 3:30 pm - 4:20 pm

Victor Barocas, a professor of biomedical engineering at the University of Minnesota, will present his lecture: “Multiscale, Multidirectional Mechanics of Ascending Thoracic Aortic Aneurysm” in 2229 of the Seamans Center on Tuesday, September 3.

 

Refreshments will be served after the seminar.

 

An abstract describing his work can be found below:

Asending thoracic aortic aneurysms (ATAAs) present a considerable therapeutic and intellectual challenge. Often undiagnosed or discovered serendipitously, ATAAs are largely asymptomatic until a catastrophic event. In addition, open repair surgery is not without risk, so there is considerable potential benefit to be gained from improved methods to predict vessel failure. In pursuing better tools, however, we must face a number of challenges and consider certain factors unique to the ATAA among blood vessels. As a general rule, ATAAs do not rupture (i.e., split the vessel along a theta-facing plane) but rather dissect (i.e., delaminate the vessel along an r-facing plane). In a nonbiological setting, such a failure mode would be associate with shear or torsion of the construct. Is shear important in the ATAA? How does the microstructure of the ATAA affect its behavior? Our group seeks to address these questions via a combination of ex vivo tissue mechanics experiments and multiscale computational studies. In addition, there is the question of how the aneurysm forms and grows. The concept of tensional homeostasis has been successful in numerous vascular remodeling studies, and it is appealing, but it is clearly a simplification of what is happening in the cell and the extracellular matrix.

The seminar will discuss our recent exploration of different approaches to modeling remodeling at the microstructural scale.

Details

Date:
September 3
Time:
3:30 pm - 4:20 pm

Venue

2229 Seamans Center
Iowa City, 52242 + Google Map
Posted on August 30th, 2019

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